The control of glycosaminoglycan structure is not well understood, but it does appear to be used to change the properties of proteoglycans to suit different biological needs. Proteoglycan forms of proteins are thus important modifiers of the organization of the pericellular and extracellular matrices and modulators of the processes that occur. The Blyscan Assay (see flowchart Fig. 1) is a quantitative dye-binding method for the analysis of sulfated proteoglycans and glycosaminoglycans. Test material can be assayed directly when present in a soluble form, or following papain extraction from biological materials. The assay can be used to measure the total glycosaminoglycans content and can also be adopted to determine the O- and N. The glycosaminoglycan chains consist of sulfate proteoglycans are present in the extracellular or basement membrane and are related to the heparan sulfate proteoglycan secreted by.
Glycosaminoglycan. Jump to navigation Jump to search. This article may be too technical for most readers to understand. Please help improve it to make it Keratan sulfate may modify core proteins through N-linked glycosylation or O-linked glycosylation of the proteoglycan Porcine dentin sialoprotein is a proteoglycan with glycosaminoglycan chains containing chondroitin 6-sulfate. J Biol Chem 280:1552-1560 ; Yamakoshi Y, Hu JC, Iwata T, Kobayashi K, Fukae M, Simmer JP. (2006). Dentin sialophosphoprotein is processed by MMP-2 and MMP-20 in vitro and in vivo. J Biol Chem 281:38235-2824 Proteoglycans represent macromolecules composed of glycosaminoglycan chains which are covalently bound to a protein core. 43 It has been demonstrated that certain proteoglycans at the cell surface are essential for the appropriate presentation of FGF-2 to its high affinity receptor. 42, 45, 65 More specifically, heparan sulfate (HS) appears to be the only glycosaminoglycan to which FGF-1 and. The rest of this sample video is available for free upon signing up for a free trial on my course website, which can be reached at the following link: https:..
Editorial on the Research Topic Proteoglycans and Glycosaminoglycan Modification in Immune Regulation and Inflammation While many publications cover proteoglycan and glycosaminoglycan (GAG. Based on the nature of the glycosaminoglycan chain, proteoglycans can be divided into several categories, including; chondroitin the main difference between a glycoprotein and a proteoglycan is that glycoproteins are lightly glycosylated and proteoglycans are heavily glycosylated. Therefore it should be proteoglycans=50%-60%. Proteoglycan‐based biomaterials are more likely to recapitulate the unique, tissue‐specific GAG profiles and native GAG presentation in human tissues. The protein core offers additional biological functionality, including cell, growth factor, and extracellular matrix binding domains, as well as sites for protein immobilization chemistries Glycosaminoglycan chain of dentin sialoprotein proteoglycan. Zhu Q(1), Sun Y, Prasad M, Wang X, Yamoah AK, Li Y, Feng J, Qin C. Author information: (1)Department of Biomedical Sciences, Baylor College of Dentistry, Texas A&M Health Science Center, 3302 Gaston Ave., Dallas, TX 75246, USA
J. 265, 289-300]. Some proteoglycan fractions were further fractionated according to hydrophobicity on octyl-Sepharose in Triton X-100 gradients. The glycosaminoglycan chains, intact or degraded by chemical or enzymic methods were then analysed by gel chromatography on Sepharose CL-6B, Bio-Gel P-6, ion exchange HPLC and gel electrophoresis. 2 Keywords: molecular dynamics; glycosaminoglycan; proteoglycan; hyaluronan; dermatan; keratan; heparan; carbohydrate conformation; carbohydrate ﬂexibility; glycosidic linkage; ring pucker; force ﬁeld; explicit solvent 1. Introduction Proteoglycans (PGs) are a diverse group of proteins in the extracellular matrix (ECM), as wel The main difference between proteoglycan and glycoprotein is that in proteoglycans, one or more glycosaminoglycan chains are attached to the protein while in glycoproteins, oligosaccharide chains are attached to proteins. Furthermore, proteoglycans mainly occur in connective tissue while glycoproteins occur in the cell membrane.. Proteoglycan and glycoprotein are two types of glycoconjugates. Glycoproteins and proteoglycans are the basic constituents of the extracellular matrix. The variations in their components gives rise to a variety of different functional molecules, each exhibiting a unique function at a unique location. This BiologyWise article compares both cellular components and lists the differences between them
tural analysis. The predominate glycosaminoglycan present in cartilage has long been known to be chondroitin sulfate.2 However, extraction of the chondroitin sulfate in a more native form, as a proteoglycan, proved to be a daunting task. The revolution in the ﬁeld came about through the work of Hascall and Sajdera.3 With the use of th Glycosaminoglycan- and Proteoglycan-Based Approaches of Cancer Therapy Chemically Modified Heparins and Glycosaminoglycans. Heparin is a potent anticoagulant used for decades to prevent and treat thromboembolism. In cancer, its anticoagulant activity affects tumor progression by decreasing thrombin generation and fibrin formation
title = Glycosaminoglycan and proteoglycan in skin aging, abstract = Glycosaminoglycans (GAGs) and proteoglycans (PGs) are abundant structural components of the extracellular matrix in addition to collagen fibers Proteoglycans. Proteoglycans (mucoproteins) are formed of glycosaminoglycans (GAGs) covalently attached to the core proteins. They are found in all connective tissues, extracellular matrix (ECM) and on the surfaces of many cell types.Proteoglycans are remarkable for their diversity (different cores, different numbers of GAGs with various lenghts and compositions)
Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics Anthony J. Hayes Bioimaging Research Hub, Cardiff School of Biosciences, Cardiff University, Cardiff, CF10 3AX Wales, U Major structural proteoglycan of cartilage extracellular matrix. Large proteoglycan with a molecular weight greater than 2,500 kDa. Approximately 100‑150 glycosaminoglycan (GAG) chains are attached to the core protein (210‑250 kDa). The majority of the GAG chains are chondroitin/dermatan sulfate with the remainder being keratan sulfate GAG chains bound to a core protein constitute a proteoglycan (PG), which is considered among the most structurally complex glycoconjugates. The core protein of a PG is synthesized by a template-driven process, after which GAG chains are added in a non-template-driven synthesis, resulting in the remarkable structural and functional diversity of PGs Proteoglycans are a ubiquitous family of heavily glycosylated molecules consisting of a core protein with one or multiple covalently-attached linear anionic glycosaminoglycan (GAG) chains. The composition of GAGs is highly diverse and depends on the coherency and expression of numerous factors, including multiple GAG-modifying enzymes F1: Schematic structure of glycosaminoglycan and proteoglycan. Note that the hyaluronic acid is not linked to a protein core. Heparan sulphate, dermatan sulphate and chondroitin sulphate are connected to proteoglycan via a serine residue
Glycosaminoglycan Lyase Digestion. Last Updated on Thu, 13 Jun 2019 | Proteoglycan. 1. Chondroitinase ABC (Proteus vulgaris), (Seikagaku America), dissolved in water at 1.0 U/mL and stored in 10-^L aliquots at -80°C for up to 3 mo (see Notes 4-6) In contrast hyaluronan, a non-sulfated glycosaminoglycan, does not form proteoglycans but mediates the formation of high-molecular-weight proteoglycan aggregates. In this special issue, various aspects of glycosaminoglycans and their biological roles are discussed The word proteoglycan helps to provide us with clues to the molecule's chemical composition. They must be at least 95% sugar by weight and have at least one glycosaminoglycan (GAG). Figure 3 Schematic diagram of a proteoglycan. The protein core has several globular domains (G1, G2, and G3), with other regions containing the keratan sulfate and chondroitin sulfate glycosaminoglycan chains. The N-terminal G1 domain is able to bind specifically to hyaluronate.This binding is stabilized by link protein Proteoglycans are one of the major components of the extracellular matrix; they act as fillers between the spaces that occur between cells. This BiologyWise post gives information on the structure of proteoglycans and its various functions in bones, cartilages, etc
. Several observations suggest that the disruption of proteoglycan synthesis rather than the presence of large amounts of free glycosaminoglycan is responsible for the inhibition of branching morphogenesis The most well studied proteoglycan, called aggrecan, is found alongside collagen as the main components of cartilage. The negative charges on the repeating glycosaminoglycan units of aggrecan attract water absorption. As a result, aggrecan acts as a cushion for impact retention by absorbing and desorbing water fated glycosaminoglycan caused a modest depression in proteoglycan synthesis, had litt~e effe~t on endogen~us proteoglycan degradation, and dl~not~nfluencethe s.lze of sulfatedproteoglycans syntheslZed by normal equme . chondrocytes inexplant culture. Considerableresearch effort has been expended in at temptsto betterunderstand andtreat. Glycosaminoglycan Sulfotransferase Osami Habuchi PG-A12 : Glycosaminoglycan Sulfotransferase-Update-Osami Habuchi PG-B01 : Interaction of L- and P-Selectin and CD44 with Versican Hiroto Kawashima PG-B02 : Heparan Sulfate Proteoglycan in the Context of Cytokines and Adhesion Molecules Yoshiya Tanaka PG-B02
Glycosaminoglycan-Protein Interactions: The First Draft of the Glycosaminoglycan Interactome Sylvain D. Vallet, Olivier Clerc, and Sylvie Ricard-Blum Journal of Histochemistry & Cytochemistry 0 10.1369/002215542094640 Cartilage proteoglycans are extracellular macromolecules with complex structure, composed of a core protein onto which a variable number of glycosaminoglycan chains are attached. Their biosynthesis at the glycosaminoglycan level involves a great number of sugar transferases well-orchestrated in Golgi apparatus. Similarly, their degradation, either extracellular or intracellular in lysosomes. Some proteoglycan fractions were further fractionated according to hydrophobicity on octyl-Sepharose in Triton X-100 gradients. The glycosaminoglycan chains, intact or degraded by chemical or enzymic methods were then analysed by gel chromatography on Sepharose CL-6B, Bio-Gel P-6, ion exchange HPLC and gel electrophoresis
proteoglycan [pro″te-o-gli´kan] any of a group of glycoproteins found primarily in connective tissue and formed of subunits of glycosaminoglycans (long polysaccharide chains containing amino sugars) linked to a protein core like bristles on a bottle brush. Hydrated proteoglycans form the highly viscous fluid of mucus and the matrix of the. Glycosaminoglycan synthesis and structure as targets for the prevention of calcific aortic valve disease K.J. Grande-Allen, K.J. Grande-Allen Nakashima et al. demonstrated that early human atherosclerosis commences with the deposition of LDL associated with the proteoglycan biglycan Proteoglycan The basic proteoglycan unit consists of a core protein with one or more covalently attached glycosaminoglycan (GAG) chain(s). The point of attachment is a Ser residue to which the glycosaminoglycan is joined through a tetrasaccharide bridge (For example: chondroitin sulfate-GlcA-Gal-Gal-Xyl-PROTEIN)
The extracellular space of animals has its own class of glycoconjugates. The cell surface and connective matrix of animal tissues have large proteoglycan molecules, which have covalently attached glycosaminoglycan chains (GAGs) that may be either N-linked or O-linked to the core protein Furthermore, in the glycosaminoglycan-free form of the part-time proteoglycan thrombomodulin, the respective serine residue is substituted with the linkage region tetrasaccharide GlcAβ1-3Galβ1-3Galβ1-4Xyl , raising the possibility that it is the transfer of the fifth monosaccharide (either GalNAc or GlcNAc) that represents the most critical step in glycosaminoglycan chain biosynthesis
The basic proteoglycan unit consists of a core protein with one or more covalently attached glycosaminoglycan chain(s). The point of attachment is a serine residue to which the glycosaminoglycan. Formato et al., Urinary glycosaminoglycan and proteoglycan excretion in normoalbuminuric patients with type 1 diabetes mellitus, Journal of Nephrology, vol. Levels of Urinary Trypsin Inhibitor and Structure of Its Chondroitin Sulphate Moiety in Type 1 and Type 2 Diabetes
lates glycosaminoglycan synthesis by retroocular tissue fibroblasts and underlies the mechanism in Graves' ophthalmopathy. Key words: cAMP, Hyaluronan, Proteoglycan, Glycosaminoglycan, Retroocular fibroblast, Graves' dis-ease (Endocrine Journal 41: 645-654, 1994) GRAVES' ophthalmopathy is considered to be a Proteoglycan. Definition. Proteoglycan is any of a group of polysaccharide-protein conjugates present in connective tissue and cartilage, consisting of a polypeptide backbone to which many glycosaminoglycan chains are covalently linked; they form the ground substance in the extracellular matrix of connective tissue and also have lubricant and support functions glycosaminoglycan lipoprotein Biosynthesis of the proteoglycan decorin. Transient 2-phosphorylation of xylose during formation of the trisaccharide linkage region, Eur J Biochem 248, 521-6 (1997). Google Scholar. 7. Moses J, Oldberg Å, Eklund E, Fransson L-Å, Biosynthesis of the proteoglycan decorin Glycosaminoglycans (GAGs) and proteoglycans (PGs) are abundant structural components of the extracellular matrix in addition to collagen fibers. Hyaluronic acid (HA), one of GAGs, forms proteoglycan aggregates, which are large complexes of HA and HA-binding PGs. Their crosslinking to other matrix proteins such as the collagen network results in the formation of supermolecular structures and. Define glycosaminoglycan. glycosaminoglycan synonyms, glycosaminoglycan pronunciation, glycosaminoglycan translation, English dictionary definition of glycosaminoglycan. n. proteoglycan, aggrecan, hyaluronic acid, and collagen II deposition and glycosaminoglycan production
Other articles where Glycosaminoglycan is discussed: human skin: The dermis: collagen, with materials known as glycosaminoglycans, which are capable of holding a large amount of water, thus maintaining the turgidity of the skin. A network of extendable elastic fibres keeps the skin taut and restores it after it has been stretched . They are polymers of acidic disaccharides containing derivatives of the amino sugars glucosamine or galactosamine.They are found primarily on cell surfaces and in the extracellular matrix.They are polar molecules and therefore attract water
Glycosaminoglycan definition is - any of various polysaccharides derived from an amino hexose that are constituents of mucoproteins, glycoproteins, and blood-group substances —called also mucopolysaccharide The corneal dermatan sulfate chains are linked to a 40-kDa protein, forming a proteoglycan of 100-150 kDa containing one or two glycosaminoglycan side chains (52). The core protein was originally characterized by its antigenic properties as decorin ( Figure 5 ), a proteoglycan present in most connective tissues and structurally related to other small interstitial proteoglycans .
Glycosaminoglycan definition, any of a class of polysaccharides derived from hexosamine that form mucins when complexed with proteins: formerly called mucopolysaccharide. See more TYPE OF PROTEOGLYCAN. Proteoglycans are one of glycoproteins, composed of a core protein with one or more covalently attached glycosaminoglycan (GAG) chain(s). There are various proteoglycans, classified in terms of which and/or how many GAGs are attached Further, while scaffold glycosaminoglycan content did not impact cell viability, heparin sulfate and chondroitin-6-sulfate containing variants increased mineral formation at the late stage of in vitro culture, respectively. Overall, these findings show scaffold microstructural and proteoglycan modifications represent a powerful tool to improve. . The glycosaminoglycans of the proteoglycans are linear polymers of up to about 200 repeating disaccharide units that consist of a hexosamine ( D -glucosamine or D -galactosamine) alternating with a uronic acid ( D -glucuronic or L -iduronic) or a neutral sugar ( D -galactose)
Porcine DSP Is a Proteoglycan N-linked and O-linked glycosylations and glycosaminoglycan attachments of porcine DSP. Panel A shows a 4-18% gradient SDS-PAGE stained with Stains-all (left), and two corresponding Western blots immunostained with the DSP antibody. Proteoglycan definition is - any of a class of glycoproteins of high molecular weight that are found especially in the extracellular matrix of connective tissue
Effects of cycloheximide, brefeldin A, suramin, heparin and primaquine on proteoglycan and glycosaminoglycan biosynthesis in human embryonic skin fibroblasts Fransson, L Å; Karlsson, P and Schmidtchen, Artur LU In Biochimica et biophysica acta 1137 (3). p.287-297. Mark; Abstrac Production of precursors: Galk1 ‡ Galactokinase 1 0.029: 5.897 0.057: 3.867 0.074: 3.043 Mm00444182_m1 Galt ‡ Gal-1-P-Uridylyltransferas Download PDF: Sorry, we are unable to provide the full text but you may find it at the following location(s): https://doi.org/10.1111/1523-1... (external link Blyscan Glycosaminoglycan Kit. Specifications; Datasheet; Product name Blyscan Glycosaminoglycan Kit Catalog number B1000 (110rxn) B3000 (440rxn) Description Quantitative dye-binding assay for analysis of sulfated proteoglycan & glycosaminoglycan ( GAG ).Can be used to measure total sulfated glycan content. Source Biocolor Product category. Proteoglycan and Glycosaminoglycan Research Reagents . Product News Mar 09, 2017 Proteoglycans are glycosylated proteins which contain covalently attached highly anionic glycosaminoglycans (GAGs). Proteoglycans are present in different forms within different types of extracellular matrices and connective tissues. Heparan sulfate.
AMSBIO has published a new 36-page catalogue that details its comprehensive range of high purity reagents for proteoglycan and glycosaminoglycan research. Proteoglycans are glycosylated proteins which contain covalently attached highly anionic glycosaminoglycans (GAGs). Proteoglycans are present in different forms within different types of extracellular matrices and connective tissues Keratinocytes and melanocytes, which together form units of structure and function within human epidermis, are known to differ in expression of autocrine growth factors, particularly those with heparin binding affinity. Because such cytokines could be regulated by the endogenous heparinlike glycosaminoglycan, heparan sulfate, proteoglycan synthesis was compared between human keratinocytes and. This free glycosaminoglycan accounts for the threefold stimulation of total glycosaminoglycan synthesis in beta- xyloside-treated cultures. Several observations suggest that the disruption of proteoglycan synthesis rather than the presence of large amounts of free glycosaminoglycan is responsible for the inhibition of branching morphogenesis
. THOMPSON and BRIAN S. SPOONER Division of Biology, Kansas State University, Manhattan, Kansas 66506 Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics. Advanced Therapeutics 2019, 2 (8) , 1900034. DOI: 10.1002/adtp.201900034 Valve proteoglycan content and glycosaminoglycan fine structure are unique to microstructure, mechanical load and age: Relevance to an age-specific tissue-engineered heart valve. Acta Biomaterialia 2008, 4 (5) , 1148-1160. DOI: 10.1016/j.actbio.2008.03.014 The cell surface and connective matrix of animal tissues have large proteoglycan molecules, which have covalently attached glycosaminoglycan chains (GAGs) that may be either N-linked or O-linked to the core protein. GAGs are linear polysaccharides that consist of repeating disaccharide units of hexuronic acid linked to a hexosamine Proteoglycan Definition noun, plural: proteoglycans A macromolecule that has a core protein attached covalently to one or more glycosaminoglycan chain Supplement Proteoglycans are macromolecules of high molecular weight and are present in the body, especially in the connective tissue s
Glycosaminoglycans (GAGs) are complex molecules composed of proteins and sugars, and are found in a variety of bodily tissues, including the blood plasma, joints, and the mucosal (mucous membrane) lining of a variety of organs, including the gastrointestinal tract and the bladder. Various compounds exist. Heparan and dermatan coat the urinary tract of cats while glucosamine and chondroitin. NG2 proteoglycan, expressed on glial progenitor cells, forms a complex with PDGF alpha-receptor and participates in PDGF signaling to promote the proliferation of these cells. RPTP zeta/beta is a brain-specific receptor-type tyrosine phosphatase bearing chondroitin sulfate chains, and could be involved in a certain signaling pathway
View This Abstract Online; Glycosaminoglycan and proteoglycan in skin aging. J Dermatol Sci. 2016; 83(3):174-81 (ISSN: 1873-569X). Lee DH; Oh JH; Chung JH. Glycosaminoglycans (GAGs) and proteoglycans (PGs) are abundant structural components of the extracellular matrix in addition to collagen fibers Start studying Glycosaminoglycan and Proteoglycan. Learn vocabulary, terms, and more with flashcards, games, and other study tools
proteoglycan from salmon nasal cartilage (sPG) (A), puriﬁed GAG (B), Glycosaminoglycan from sPG, hyaluronan (HA) (C), CS6M (D), where 6 sulfate of chondroitin is the major, CS4M (E), where 4 sulfate of chondroitin is the major, glucosamine hydrochloride (GlcN) (F) and type I collagen (G) A powerful approach for studying the relationship of proteoglycan (PG) structure to function employs inhibitors to block glycosaminoglycan (GAG) biosynthesis. Although true enzyme-based, active site-directed inhibitors of the glycosyltransferases and sulfotransferases have not yet been described, decoys consisting of β-D-xylose linked to hydrophobic aglycones have been available for some time. This was demonstrated, in an indirect immunocytochemical study, through the use of monoclonal antibodies that detect structurally distinct domains in glycosaminoglycan chains of proteoglycans. Using samples of normal human skin obtained from individuals ranging in age from 20 weeks of gestation to 98 years of age, we determined that a common distribution pattern existed in skin Glycosaminoglycan과 proteoglycan은 연골의 주요성분이고 연골은 관절을 보호해 주는 기능을 합니다. 따라서 글루코사민을 먹으면 관절통증이 낫는다고 이렇게 선전들을 하는 것이지요. 그럼 이제부터 우리몸에 중요한 glycosaminoglycan과 proteoglycan에 대해서 알아보겠습니다 Question: Proteoglycans Are Part Of The Extracellular Matrix; They Provide Structure, Viscosity And Lubrication, And Adhesiveness. They Are Composed Of Proteins Conjugated To Carbohydrate Components Called Glycosaminoglycans. The Glycosaminoglycan Component Makes Up The Majority Of The Mass Of A Proteoglycan
When the proteoglycan is complete, it leaves the cell through secretory vesicles, and enters the extracellular matrix. A group of genetic metabolic disorders known as mucopolysaccharidoses are characterized by the inability to break down proteoglycans due to absent or malfunctioning lysosomal enzymes The aim of this study is to review developments in glycosaminoglycan and proteoglycan research relevant to cartilage repair biology and in particular the treatment of osteoarthritis (OA). Glycosaminoglycans decorate a diverse range of extracellular matrix and cell associated proteoglycans conveying structural organization and physico‐chemical properties to tissues IGF-I affects glycosaminoglycan/proteoglycan synthesis in breast cancer cells through tyrosine kinase-dependent and -independent pathway Proteoglycans are natural macromolecules that are capable of restoring epidermal cells and intensifying the metabolism of connective tissue components, restoring the skin's functions, mechanical properties and physiological appearance. They are formed by a carrier protein that different glycosaminoglycan (GAG) chains are covalently attached to: hyaluronic acid, chondroitin sulphate/dermatan.
Braz J Med Biol Res, August 2003, Volume 36(8) 1079-1089. Decorin is one of the proteoglycans expressed in Walker 256 rat mammary carcinoma. S.M. Oba-Shinjo, A.G.A. Read Effect of Polysulfated Glycosaminoglycan on DNA Content and Proteoglycan Metabolism in Normal and Osteoarthritic Canine Articular Cartilage Explants, Veterinary Surgery on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips Define proteoglycan. proteoglycan synonyms, proteoglycan pronunciation, proteoglycan translation, English dictionary definition of proteoglycan. n. Any of various glycoproteins that have glycosaminoglycan chains attached by covalent bonds to the protein, usually found in the extracellular matrix of.. T1 - Post-translational modifications of α5β1 integrin by glycosaminoglycan chains. The α5β1 integrin is a facultative proteoglycan. AU - Veiga, Silvio S. AU - Elias, Maria Carolina Q.B. AU - Gremski, Waldemiro. AU - Porcionatto, Marimelia A. AU - Da Silva, Roseli. AU - Nader, Helena B. AU - Brentani, Ricardo R. PY - 1997/5/9. Y1 - 1997/5/
The function of these two glycosaminoglycan side chains is opposite. The presence of a KS side chain in adult proteoglycan inhibits the recognition of arthritogenic T cell epitopes, prevents the development of T cell response, and protects animals from autoimmune arthritis T1 - High Glucose Alters Proteoglycan Expression and the Glycosaminoglycan Composition in Placentas of Women with Gestational Diabetes Mellitus and in Cultured Trophoblasts. AU - Chen, C. P. AU - Chang, S. C. AU - Vivian Yang, W. C. PY - 2007/2. Y1 - 2007/ proteoglycan definition: nounAny of various glycoproteins that have glycosaminoglycan chains attached by covalent bonds to the protein, usually found in the extracellular matrix of connective tissue... Dung beetle glycosaminoglycan is known to possess anti-aging activities. However, its anti-cancer mechanisms are not fully elucidated yet. The objective of this study was to evaluate the anti-cancer effect of insect-derived polymer dung beetle glycosaminoglycan (GAG) after intraperitoneally injecting it to melanoma mice induced by B16F10 cells sulfate proteoglycan biosynthetic process, enzymatic modification • glycosaminoglycan biosynthetic process • protein sulfation Sources:Amigo / QuickGO NDST3 (511 words) [view diff] exact match in snippet view article find links to articl